- The cat who lived with Anne Frank, David Lee Miller and Steven Jay Rubin ; illustrated by Elizabeth Baddeley
- Grace Banker and her Hello Girls answer the call, the heroic story of WWI telephone operators, written by Claudia Friddell ; illustrated by Elizabeth Baddeley
- The science of baking, by Andrea Beaty and Dr. Theanne Griffith ; illustrations by Steph Stilwell
- Brains on! presents...Earth friend forever, Molly Bloom, Marc Sanchez, and Sanden Totten ; illustrated by Mike Orodán
- The best American science and nature writing 2021, Ed Yong, editor
- Midnight's borders, a people's history of modern India, Suchitra Vijayan
- Yayoi Kusama covered everything in dots and wasn't sorry, by Fausto Gilberti
- An American quilt, unfolding a story of family and slavery, Rachel May
- Ocean, by Emmy Kastner
- Beware the Burmese pythons and other invasive animal species, written by Etta Kaner ; illustrated by Phil Nicholls
- How science saved the Eiffel tower, by Emma Bland Smith ; illustrated by Lia Visirin
- Drop, an adventure through the water cycle, Emily Kate Moon
- Mars!, Earthlings welcome, by Mars ; (with Stacy McAnulty) ; illustrated by Mars (and Stevie Lewis)
- Mars!, Earthlings welcome, by Mars (with Stacy McAnulty) ; illustrated by Mars (and Stevie Lewis)
- The price of the ticket, collected nonfiction, 1948-1985, James Baldwin
- Cat, written by Juliet Clutton-Brock
- I am I.M. Pei, Brad Meltzer ; illustrated by Christopher Eliopoulos
- Duke Ellington's Nutcracker suite, Anna Harwell Celenza ; illustrated by Don Tate
- Emmet to the rescue, by Julia March
- She caught the light, Williamina Stevens Fleming : astronomer, written by Kathryn Lasky ; illustrated by Julianna Swaney
- Our very own dog, Amanda McCardie ; illustrated by Salvatore Rubbino
- Marcel's masterpiece, how a toilet shaped the history of art, Jeff Mack
- Birds of prey, terrifying talons, Joe Flood
- Jane against the world, Roe v. Wade and the fight for reproductive rights, Karen Blumenthal
- Hiders seekers finders keepers, how animals adapt in winter, written by Jessica Kulekjian ; illustrated by Salini Perera
- Elephants remember, a true story, Jennifer O'Connell
- Fighting for independence, an interactive American Revolution adventure, by Blake Hoena consultant : Richard Bell, PhD Associate Professor of History University of Maryland, College Park
- Ducks overboard!, a true story of plastic in our oceans, Markus Motum
- Hold on to your music, the inspiring true story of the children of Willesden Lane, by Mona Golabek and Lee Cohen ; adapted by Emil Sher ; illustrated by Sonia Possentini
- I'm a volcano!, by Bridget Heos ; illustrated by Mike Ciccotello
- Ocean!, waves for all, by Ocean (with Stacy McAnulty) ; illustrated by Ocean (and David Litchfield)
- Ocean!, waves for all, by Ocean (with Stacy McAnulty) ; illustrated by Ocean (and David Litchfield)
- The secret life of viruses, incredible science facts about germs, vaccines, and what you can do to stay healthy, Mariona Tolosa Sisteré, The Ellas Educan Collective
- Emily writes, Emily Dickinson and her poetic beginnings, Jane Yolen ; illustrated by Christine Davenier
- I'm trying to love math, words & pictures by Bethany Barton
- The view from the cheap seats, selected nonfiction, Neil Gaiman
- The Invention Hunters discover how electricity works, written and illustrated by Korwin Briggs
- So you want to be an owl, Jane Porter ; illustrated by Maddie Frost
- Hear my voice, the testimonies of children detained at the southern border of the United States, compiled by Warren Binford for Project Amplify ; foreword by Michael Garcia Bochenek of Human Rights Watch = Escucha mi voz : los testimonios de niños detenidos en la frontera sur de los Estados Unidos / recopilado por Warren Binford para Project Amplify ; prefacio por Michael Garcia Bochenek
- Why we swim, Bonnie Tsui
- Still no word from you, notes in the margin, Peter Orner
- Grandma's gardens, written by Hillary Clinton and Chelsea Clinton ; illustrated by Carme Lemniscates
- The whale who swam through time, a 200-hundred-year journey in the Arctic, written by Alex Boersma and Nick Pyenson ; illustrated by Alex Boersma
- The address book, what street addresses reveal about identity, race, wealth, and power, Deirdre Mask
- Queens & kings and other royal rotters, by Adam and Lisa Murphy
- I am the shark, written by Joan Holub ; illustrated by Laurie Keller
- Narwhal on a sunny night, by Mary Pope Osborne ; illustrated by AG Ford
- The Pilgrims' voyage to America, by Thomas Kingsley Troupe ; illustrated by Jomike Tejido
- 111 trees, how one village celebrates the birth of every girl, [text] Rina Singh ; [illustrator] Marianne Ferrer
- The case of the murderous Dr. Cream, the hunt for a Victorian era serial killer, Dean Jobb